Fig. 10: Drug sensitivity profiling.
From: A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
a Rank ordered plot measuring population doubling times (time-lapse microscopy). b Cell fate profiles of untreated cultures and following exposure to paclitaxel, with each horizontal line showing the behaviour of a single cell and the columns quantitating specific cell fates. c Line graphs using green object count (GOC) to measure nuclear proliferation of sample OCM.46 in response to increasing concentrations of cisplatin and paclitaxel, plus corresponding IC50 curves. d Dot plots showing IC50 values for cisplatin (rank ordered) and paclitaxel. Asterisk represents p < 0.05 for comparison of the sensitivity of OCMs 64–3Ep− and 64–3Ep+ to cisplatin (one-way ANOVA; Tukey’s multiple comparison). In a and d, lines represent mean and standard deviation from at least three biological replicates. In c lines show mean and standard deviation from three technical replicates. See also Supplementary Fig. 5. Source data for panels a and d are provided as a Source Data file.
