Fig. 9: Mitosis in 3D.
From: A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
a Z-stack projections showing examples of abnormal mitoses in OCM.66–1 from three biological replicates when cultured in 3D. Numbers show minutes after imaging initiated. Scale bar, 20 µm. Arrowhead shows unaligned chromosomes at anaphase, arrow shows an ejected chromosome. b Quantitation of mitotic anomalies with each column representing one cell and the vertical grey bars representing the time each cell spent in mitosis. c Violin plot showing the time spent in mitosis for OCM.66–1 when cultured in 3D. Lines show the median and interquartile ranges. The 2D data from Fig. 8b is for comparison only. Source data for panels b and c are provided as a Source Data file.
