Fig. 1: Dynamic covalent assembly of encoded molecular ladders.
From: Sequence-selective dynamic covalent assembly of information-bearing oligomers
a Structures of complementary, mass-labeled precursor peptoids and desired, in-registry molecular ladder product. b MALDI mass spectra of molecular ladder reaction mixtures generated either after a single-step, deprotection, and direct assembly process (bottom, black), or via a stepwise, dissociation/extraction/annealing assembly process (top, red). Peaks at multiples of +18m/z values are attributable to ladders species with fewer rungs (e.g., y = in-registry, 5-rung 10101 × 01010 molecular ladder, y−1 = out-of-registry, 4-rung 10101 × 01010 molecular ladder, etc.). c MALDI mass spectra of the reaction mixture initially containing 10101 and 01010 sequences and a high loading of Sc(OTf)3 (bottom, black), immediately after aqueous extraction (middle, red), and after annealing at 70 °C for 2 h (top, blue). Expected exact masses: [M01010 + Na]+ = 1651.83; [M10101 + Na]+ = 1767.92; [M01010×01010 + Na]+ (x) = 3208.63; [M10101×01010 + Na]+ (y) = 3306.71; [M10101×10101 + Na]+ (z) = 3440.81.
