Fig. 2: Reactivity toward cells with overexpression of immunoproteasome subunits is higher compared to control. | Nature Communications

Fig. 2: Reactivity toward cells with overexpression of immunoproteasome subunits is higher compared to control.

From: Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

Fig. 2

a Cells with immunoproteasome overexpression compared to empty vector control or cells treated with IFNγ compared to untreated cells were co-cultured in different ratios with autologous TILs. (E:T, different effector to target ratios). Number of live cells were counted after 8 or 12 h for 12T and 108T, respectively. b IFNγ secretion was measured after 2, 4, 6, and 8 h of co-culture of cells with immunoproteasome overexpression compared to empty vector control or cells treated with IFNγ compared to untreated cells. Data were analyzed from n = 3 biological repeats per each condition and represented as mean ± SD.

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