Fig. 3: Differently presented peptide repertoire in cells with immunoproteasome overexpression. | Nature Communications

Fig. 3: Differently presented peptide repertoire in cells with immunoproteasome overexpression.

From: Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

Fig. 3

Volcano plots were plotted to identify the peptides that were differentially presented by cells with overexpression of the immunoproteasome subunits (OE) compared to the control (EV) (a–c), or of the cells that were treated with IFNγ (IFNγ) compared to non-treated cells (NT) (d, e). Each HLA peptidomics experiment was done on three independent cell cultures. Peptides were determined as significantly changed if they passed statistical analysis (Two side student’s t-test, permutation based FDR = 0.05, S0 = 1) and were found in the plot above the lines. TAAs were marked in blue dots and neo-antigens in red dots. The number of differentially presented peptides is indicated in the table (f).

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