Fig. 1: Clinical associations with somatic alterations in OS.

a, b Kaplan-Meier survival analysis (disease-free survival for a; overall survival for b) of mutation signature 8 scores which describe the contribution of mutation signature 8 to the point mutation profile. The cohort was separated into tertiles based on signature 8 scores. Group 1 (denoted as T1) is the first tertile with lowest mutation signature 8 scores. Groups 2 and 3 (denoted as T2 and T3 respctively) are the next 2 tertiles with higher mutation signature 8 scores. c Hierarchical clustering heatmap of rearrangements classification pattern identified in our cohort along with clinical features: age of diagnosis (<18 years, 18– < 50 years, and >50 years), tumor specimen type (primary, local recurrence, metastasis), and vital status (dead, alive). Structural rearrangements were classified based on their type: deletion (del), tandem duplication (tds), inversion (inv), and interchromosomal translocation (trans), and size, and clustered (denoted as c_) versus non-clustered events. d Boxplot showing the ratio of clustered rearrangements within associated with chromothriptic regions as compared across three groups of specimens based on age of diagnosis (<18 years, 18–<50 years, and >50 years). Then significance values (P-values) of the comparisons are from the Wilcoxon rank sum test are shown in asterisks. e Pearson correlation between normalized telomere length and number of copy number segments of samples. f Pearson correlation between normalized telomere length and ATRX gene expression level (in log2 scale) of samples. Samples with both ATRX and TP53 alterations, ATRX alterations alone, and TP53 alterations alone were respectively marked as red, blue, and green color.