Table 1 Clinical characteristics of 48 patients with osteosarcoma.
Characteristic | n (%) |
|---|---|
Median age at diagnosis in years (range) | 27 (5-81) |
Gender | |
 Male | 29 (60) |
 Female | 19 (40) |
Race | |
 White | 30 (63) |
 Hispanic | 10 (21) |
 Black | 5 (10) |
 Asian | 3 (6) |
Disease stage at presentation | |
 Localized | 37 (77) |
 Metastatic | 11 (23) |
Histologic subtype | |
 Osteoblastic | 14 (29) |
 Fibroblastic | 9 (19) |
 Chondroblastic | 6 (13) |
 Extraskeletal | 6 (13) |
 Dedifferentiated parosteal | 5 (10) |
 Telangiectatic | 2 (4) |
 Giant cell rich | 1 (2) |
 High-grade surface | 1 (2) |
 Other—high grade | 4 (8) |
Pathologic response to neoadjuvant chemotherapy (n = 41 patients)* | |
 Good (tumor necrosis ≥ 90%) | 11 (27) |
 Poor (tumor necrosis < 90%) | 30 (73) |
Vital status | |
 Alive | 16 (33) |
 Dead | 32 (67) |
Specimen type (n = 54)** | |
 Primary tumor | 14 (26) |
 Local recurrence | 13 (23) |
 Metastasis | 27 (51) |
Testing platforms (number of specimens)** | |
 Whole genome sequencing (WGS) | 35 |
 RNA sequencing (RNAseq) | 51 |
 Reverse phase protein prray (RPPA) | 38 |
 T-cell receptor sequencing (TCR) | 41 |
 Immunohistochemistry | 33 |
