Fig. 7: Summary Scheme: PFC-PVIs show decreased excitability and drive following juvenile social isolation, a manipulation that leads to decreased social interaction. | Nature Communications

Fig. 7: Summary Scheme: PFC-PVIs show decreased excitability and drive following juvenile social isolation, a manipulation that leads to decreased social interaction.

From: Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

Fig. 7

In group housed adults, short dmPFC-PVI activation induced by optogenetics mirrors naturally observed pre-active dmPFC-PVI activity, and leads to social approach. This relationship is not observed in juvenile socially isolated mice. Decreased social interaction can be induced in group housed animals by inhibiting PFC-PVI in adult mice; social interaction of isolated mice can be mitigated by increasing PFC-PVI activity.

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