Fig. 3: Global SREBP-signaling requires SPRING. | Nature Communications

Fig. 3: Global SREBP-signaling requires SPRING.

From: Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Fig. 3

a–d Comparison of transcriptional profiles obtained by RNAseq of a Hap1-WT and Hap-SPRINGKO cells, and b–d the transcriptional response of the indicated cells to sterol depletion. SREBP target genes (HMGCR, HMGCS1, SQLE, ACACA, ACAT2, ACSS2, CYP51A1, DHCR24, DHCR7, EBP, FASN, FDFT1, FDPS, GGPS1, GGPS1, HSD17B7, IDI1, INSIG1, LDLR, LSS, MVD, MVK, NSDHL, PCSK9, SC5D, SCD1, SREBF2, TM7SF2)4,18 are shown in red and SPRING in green.

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