Fig. 8: Model of the AMPK-dependent activation of Cyclin Y/CDK16 for the induction of autophagy. | Nature Communications

Fig. 8: Model of the AMPK-dependent activation of Cyclin Y/CDK16 for the induction of autophagy.

From: AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Fig. 8

AMPK is activated under energy stress situations (- amino acids; - glucose) or by allosteric activators (AICAR/A769) and phosphorylates Cyclin Y at S326. This phosphorylation allows the interaction of Cyclin Y with CDK16 and stimulates the kinase activity of CDK16, as illustrated by the phosphorylation of Cyclin Y at S336. The CDK16 activity downstream of AMPK is required for the efficient induction of autophagy.

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