Fig. 7: Autism-like behaviors and most PV interneuron properties were normalized in PV-DKO mice. | Nature Communications

Fig. 7: Autism-like behaviors and most PV interneuron properties were normalized in PV-DKO mice.

From: Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors

Fig. 7

a–b Social interaction and repetitive behaviors. DKO, n = 11 (a), 17 (grooming) and 11 (digging). c c-Fos+ L2/3 ACC neurons in naïve mice and after social interaction. *, **, **** are SI compared to NSI for each genotype. n = 4 mice per genotype per condition. In PV-DKO mice, PV neurons showed normalized (d) resting membrane potential (n = 11 cells/5 WT mice, 20 cells/7 DKO mice), e cell membrane excitability plotted as the AP# for a given current injection, fitted to a sigmoidal function, f latency for the first spike at various current injections, fitted to exponential decay, and g resting membrane conductance. h I-V curves of WT (black) and PV-Lmo4KO (KO, red) and DKO (blue) revealed normalized leak conductance and augmented (over-compensated) delayed rectifier conductance of PV-DKO mice. i The subtraction of I-V curves between DKO and WT is shown and exponentially fitted. Boxed insets (h, i) show expanded current scales; i inset: isolated delayed rectified potassium currents. n = 10 cells/5 WT, 12 cells/5 KO, 18 cells/7 DKO for (e–i). *, **, ##, ****, p < 0.05, 0.01, 0.01, 0.0001, respectively.

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