Fig. 3: Per-cell mutation and per-cell survival rate inferences in healthy haematopoiesis during development.
From: Measuring single cell divisions in human tissues from multi-region sequencing data
a Mutational distance distribution inferred from 89 whole-genome sequenced healthy haematopoietic stem cells from ref. 13 (black dots), and best theoretical fit (grey line). Posterior parameter distribution of the MCMC inference for b the mutation rate per cell division (\(\mu L = 1.14_{ - 0.24}^{ + 0.12}\) mutations per genome per cell division) and c the cell survival rate (\(\beta = 0.96_{ - 0.102}^{ + 0.038}\)). Median point estimates and 95% credibility intervals were taken from the posterior parameter distributions. The inferred mutation rate per cell division agrees with the original estimation of 1.2 mutations per cell division. Furthermore, our joined inference of mutation and cell survival rate confirms the original assumption of no cell death during early development of haematopoiesis.
