Fig. 6: Map of per-cell mutation and per-cell survival rates across cancer types.
From: Measuring single cell divisions in human tissues from multi-region sequencing data
For each of the 16 tumours analysed we plot the per-cell mutation rate versus the per-cell survival rate. Median estimates and 95% credibility intervals for the mutation and cell survival rate are derived from the MCMC inferences as described in the main text. Dashed lines correspond to values of healthy tissue (μh = 1 × 10−9, βh = 1/3). White background corresponds to β values that allow for growing cell populations as β = 1/3 corresponds to stable (homeostatic) populations. Shaded area describes values of β that would lead to population extinction. Most cancers scatter across the map, indicating extensive inter-patient heterogeneity.
