Fig. 3: Whole-brain characterisation of the changes in rCBF associated with each method of administration.

For each time-point, we compared CBF maps between treatment and placebo using Paired T-contrasts, accounting for global CBF as a nuisance variable. We conducted cluster-level inference, reporting clusters significant at p < 0.05 FWE-corrected (cluster-forming threshold: p < 0.005, uncorrected). Images are shown as t-statistics in radiological convention. Blue and red indicate decreases and increases in rCBF, respectively. The first row (Panel a) refers to rCBF changes associated with the nasal spray, the second (Panel b) with the intravenous administration and the third one (Panel c) with the PARI SINUS nebulizer.