Table 3 Paired t-contrasts comparing intravenous OT administration to placebo/saline.

From: Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Cluster description

Hemisphere

K

PFWE

Peak Coordinates

Description

x

y

z

Intravenous < placebo (24–32 min)

 Cluster 1: parahippocampal gyrus, pallidum, amygdala, insula

Left

1159

<0.001

−12

4

−2

Left pallidum

−16

2

−20

Left enthorinal area/amygdala

−38

2

−10

Left anterior insula

Intravenous < placebo (87–95 min)

 Cluster 2: anterior cingulate, superior frontal gyrus, orbitofrontal cortex

Bilateral

1179

<0.001

6

42

16

Right anterior cingulate

14

62

12

Right superior frontal gyrus

10

56

−6

Right superior frontal gyrus

  1. We compared CBF maps following intravenously administered OT and placebo/saline using paired t-contrasts at each time-interval (to capture the direction of potential rCBF changes), controlling for global CBF as a nuisance variable. We conducted cluster-level inference, reporting clusters significant at p < 0.05 FWE-corrected (cluster-forming threshold: p < 0.005, uncorrected). Clusters that do not survive correction for multiple testing following adjustment of the P-value using Bonferroni correction for the 24 paired-t-tests performed are denoted by an asterisk (*) (Padjusted = 0.05/24 = 0.002).
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