Table 4 Paired t-contrasts comparing OT administered with the nebulizer to placebo/saline.

Cluster description	Hemisphere	K	P_fwe	Peak coordinates			Description
Cluster description	Hemisphere	K	P_fwe	x	y	z	Description
Nebulizer < placebo (15–23 min)
Cluster 1: caudate, putamen, pallidum*	Left	434	0.037	−18	0	20	Left caudate
				−12	8	8
				−6	2	16
Nebulizer > placebo (24–32 min)
Cluster 2: superior, middle and inferior occipital gyrus, calcarine sulcus, cuneus	Bilateral	1154	<0.001	52	−74	−8	Right inferior occipital gyrus
				38	−92	−2
				40	−88	−14
Cluster 3: cerebellum*	Right	457	0.033	26	−72	−28	Right cerebellum
				12	−82	−28
				4	−86	−38
Nebulizer > placebo (75–83 min)
Cluster 4: postcentral gyrus, superior, middle and inferior occipital gyrus, superior parietal gyrus, inferior and middle temporal gyrus, precuneus, calcarine sulcus, cuneus	Right	2546	<0.001	56	−66	−16	Right inferior temporal gyrus
				28	−54	72	Right Superior Parietal Lobule
				48	−78	−16	Right inferior occipital gyrus
Nebulizer < placebo (75–83 min)
Cluster 5: caudate, putamen, pallidum, thalamus, amygdala, hippocampus, olfactory region, insula	Left	1229	<0.001	−14	0	18	Left caudate
				−12	−14	−10	Left ventral diencephalon
				−6	−6	4	Left thalamus

We compared CBF maps following OT administered with the nebulizer to placebo/saline using paired t-contrasts at each time-interval (to capture the direction of potential rCBF changes), controlling for global CBF as a nuisance variable. We conducted cluster-level inference, reporting clusters significant at p < 0.05 FWE-corrected (cluster-forming threshold: p < 0.005, uncorrected). Clusters that do not survive correction for multiple testing following adjustment of the P-value using Bonferroni correction for the 24 paired-t-tests performed are denoted by an asterisk (*) (P_adjusted = 0.05/24 = 0.002).

Quick links

Search