Fig. 5: B38-CAP suppresses TAC-induced cardiac fibrosis.
From: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
a, b Histology. The hearts of B38-CAP or vehicle-treated mice under TAC were stained with Masson’s trichrome. Bars indicate 1 mm (upper) or 100 μm (lower). c–h qRT-PCR analysis for the expression of heart failure genes and pro-fibrosis genes; mRNA levels of atrial natriuretic factor (ANF) (c), B-type natriuretic peptide (BNP) (d), β-myosin heavy chain (β-myhc) (e), Collagen 8a (Col8a1) (f), Periostin (Postn) (g), and TGF-β (Tgfb2) (h) in the hearts of mice treated with sham + vehicle (n = 7), sham + B38-CAP (n = 5), TAC + vehicle (n = 9), and TAC + B38-CAP (n = 8). All values are means ± SEM. b–h Two-way ANOVA with Sidak’s multiple-comparisons test. Numbers above square brackets show significant P-values.
