Fig. 6: Comparison of inactive GLP-1R and GCGR.
From: Full-length human GLP-1 receptor structure without orthosteric ligands
a Different structural motifs of the stalk, ECL1 and ECL3 between GLP-1R and GCGR in their respective inactive conformations. TMDs of GLP-1R and GCGR are shown as blue and grey cartoons, respectively, while their ECL1 and ECL3 are shown as red (GLP-1R) and pink (GCGR) cartoons, and ECDs are labelled and shown as surfaces. b Zoom-in views of the key differences in stalk, ECL1 and ECL3. c Alignments of key residues in stalk, ECL1, ECL2 and ECL3 between GLP-1R and GCGR. β-branched and glycine residues are colored blue and red, respectively. The conserved hydrophobic, neutral hydrophilic, acidic and basic residues are shown with grey, cyan, red and blue backgrounds, respectively. Underline indicates the highly entropic region in GLP-1R.
