Fig. 1: Distribution of predicted blood cell type proportions (CTPs) in PD and controls. | Nature Communications

Fig. 1: Distribution of predicted blood cell type proportions (CTPs) in PD and controls.

From: Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Fig. 1

Boxplots of predicted blood CTPs in 1638 unrelated European individuals from the SGPD data set, stratified by PD status (851 PD cases, 787 controls). B cells, p = 2.16 × 10−10; CD4T cells, p = 2.97 × 10−15; CD8T cells, p = 5.29 × 10−03; eosinophils (eos) cells, p = 1.43 × 10−01; monocytes (mono) cells, p =  2.22 × 10−02; neutrophils (neu) cells, p < 2 × 10−16; natural killer (NK) cells, p = 7.53 × 10−05; granulocytes, p < 2 × 10−16. P values from logistic regression of PD status on predicted age, sex, and individual cell types. Granulocytes are calculated as the sum of eosinophil and neutrophil proportions. Boxplot center lines show the median, box limits denote upper and lower quartiles, whiskers represent 1.5 ×  interquartile range and individual points show outliers.

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