Fig. 1: Spontaneous checkerboard patterning with optogenetically emulated cell-to-cell signaling.
From: Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
Optogenetically responsive cells signal to each other through computer-controlled light inputs that vary in intensity based on the gene expression levels of other cells. We enact lateral inhibition according to the theory in Section 3.1 that predicts when cells will spontaneously separate into two classes of high and low gene expression. In all figures, red denotes in vivo and blue denotes in silico components.
