Table 1 Optimization of reaction conditionsa.
From: Visible-light promoted regioselective amination and alkylation of remote C(sp3)-H bonds
| ||
|---|---|---|
Entry | Change to “condition A” | Yield (%)b |
1 | Condition A | 73 |
2 | No light | 0 |
3 | No photocatalyst | 0 |
4 | Without K2CO3 | 0 |
5 | A,B,C,D instead of G | 0 |
6 | E, F, H instead of G | 20–64 |
7 | Other bases instead of K2CO3 | 0–49 |
8 | Other solvents instead of DMF | 0–55 |
- aUnless noted, the reactions were carried out using 1a (0.1 mmol), 2a (3 equiv), photocatalyst (1 mol %), base (3.0 equiv), and DMF (1 ml), under Ar, and stirred at rt for 12 h under 24-W violet LED irradiation.
- bIsolated yields.
