Table 1 Parameter values inferred for progenitor cell behavior in different murine epithelial regions as derived from quantitative lineage tracing.

From: A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice

Tissue

Experimental model

Reference

min tcc (days)

Division rate, λ (/week)

Symmetric division prob., r

% of progenitor cells, ρ

Stratification rate, Γ (/week)

Esophagus

Lrig1-eGFP-CreERT/R26-flConfetti

 

0.5

2.9 (2.7; 3.0)

0.10 (0.07; 0.15)

65 (50; 96)

5.4 (2.9; 69.6)

 

Ah-CreERT/R26flEYFP

5

0.5

2.9 (2.7; 3.0)

0.06 (0.04; 0.10)

56 (50; 89)

3.7 (2.9; 23.5)

Paw Epidermis

Axin2-CreERT2/R26-Rainbow

11

1

2.0 (1.7; 2.3)

0.14 (0.12; 0.17)

53 (49; 58)

2.3 (1.9; 2.8)

Ear Epidermis

Ah-CreERT/R26flEYFP

32

1

1.5 (1.2; 1.7)

0.04 (0.03; 0.06)

54 (47; 72)

1.8 (1.3; 3.9)

Back Epidermis

Ah-CreERT/R26flEYFP

22

2

1.2 (1.1; 1.3)

0.04 (0.03; 0.07)

61 (55; 76)

1.9 (1.5; 3.8)

  1. Parameter values indicated correspond with the maximum likelihood estimate (MLE), values in parentheses are 95% confidence bounds (see Supplementary Methods for details).
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