Fig. 6: TEADi expression in the mouse skin induces wounding and inflammation. | Nature Communications

Fig. 6: TEADi expression in the mouse skin induces wounding and inflammation.

From: YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

Fig. 6

a Histology and IF pictures of the skin of a TEADi-expressing mouse showing a wound area and the surrounding epithelium. b Representative IF pictures of the skin of WT or TEADi mice induced for 12 days to show expression of the proliferation marker PCNA and the basal marker KRT5. c Representative IF picture of the skin of TEADi mice induced for 12 days to show expression of the proliferation marker PCNA and GFP. d Representative IF pictures and quantification of the skin of TEADi mice induced for 4 and 12 days to show expression of GFP. e Representative IF pictures and quantification of immune cell infiltration labeled by CD45 staining in the skin of TEADi mice. Inserts show magnification of the highlighted area. Location of the basal membrane is indicated with a white dotted line. In d 4d n = 69 and 12d n = 61; (e) WT n = 107, 4d n = 106 and 12d n = 114 fields from 3 different mice in each condition. Violin plots shows density of data and box plot shows median, 25 and 75% quartile, 95% confidence interval and dots indicating potential outliers; in d two-tailed unpaired t test and in e two-way ANOVA with Dunnett’s multiple comparison test. Source data are provided as a Source Data file.

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