Fig. 7: TEAD regulation of keratinocyte proliferation and differentiation. | Nature Communications

Fig. 7: TEAD regulation of keratinocyte proliferation and differentiation.

From: YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

Fig. 7

a Simplified model summarizing the results from our study. Blockage of TEAD activation by TEADi triggers differentiation and reduced proliferation. In turn, activation of KLF4 can also lead to inhibition of YAP1/TAZ-TEAD transcription. b Comparison between the model of action of TEADi vs siYAP1/TAZ which might explain the lack of complete overlap in gene networks under both conditions. In cells expressing TEADi, YAP1/TAZ can still directly or indirectly regulate other factors that regulate transcription (TFs) and maintain cytoplasmic complexes, conditions that are not reproduced under YAP1/TAZ knockdown. Created with BioRender.

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