Table 5 Characteristics of total case cohort.

From: Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes

Ā 

Number (%)

Total patients

516 (100)

Age at diagnosis of ovarian carcinoma

ā€ƒ<30

5 (1)

ā€ƒ30āˆ’39

14 (3)

ā€ƒ40āˆ’49

72 (14)

ā€ƒ50āˆ’59

149 (29)

ā€ƒ60āˆ’69

176 (34)

ā€ƒ70āˆ’79

80 (15)

ā€ƒā‰„80

20 (4)

Histopathology

ā€ƒHigh-grade serous (incl. carcinosarcoma)

443 (86)

ā€ƒHigh-grade endometrioid

35 (7)

ā€ƒMixed epithelial (with predominant high-grade serous component)

11 (2)

ā€ƒSerous (grade unknown/uncertain, presumed high-grade)

5 (1)

ā€ƒAdenocarcinoma NOS (presumed high-grade serous)

9 (2)

ā€ƒUnknown (presumed high-grade serous)

13 (2)

Personal history of cancer

ā€ƒBreast (excl. DCIS)

47 (9)

ā€ƒOther (incl. breast DCIS)

62 (12)

ā€ƒNo history of cancer

407 (79)

Family history of ovarian or breast cancer (first- and second-degree relatives only)

ā€ƒOne ovarian cancer case (no breast cancer)

46 (9)

ā€ƒā‰„2 ovarian cancer cases (no breast cancer)

4 (1)

ā€ƒOne breast cancer case (no ovarian cancer)

131 (25)

ā€ƒā‰„2 breast cancer cases (no ovarian cancer)

47 (9)

ā€ƒā‰„2 ovarian and breast cancer cases

34 (7)

ā€ƒNo known cases of breast or ovarian cancer

254 (49)

  1. NOS not otherwise specified, DCIS ductal carcinoma in situ.