Fig. 3: Differential TF binding activity between PAH and controls. | Nature Communications

Fig. 3: Differential TF binding activity between PAH and controls.

From: Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Fig. 3

a Circular vulcano-plot shows the distribution of differential TF activity based on H3K27ac signal differences between PAH and controls. TFs previously associated with PAH are labeled in black. TFs that are more differentially active between patients and controls than the known PAH-TFs are labeled in red. Full list of differentially active TFs are provided in Supplementary Data 3. b Enrichment of known TFs related to PAH among the set of differentially active TFs for increasing thresholds for defining differential TF activity. TF activity is shown on an absolute scale with TFs being more active in patients and controls colored in orange and blue, respectively.

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