Fig. 5: Functional analysis of genes targeted by differential PAH-TFs. | Nature Communications

Fig. 5: Functional analysis of genes targeted by differential PAH-TFs.

From: Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Fig. 5

a Enrichment of gene ontology (GO) annotations for target genes in PAH-specific GRN (adj. p-val < 0.05). Only GO terms that have between 3 and 80 genes are shown and some highly redundant terms were removed (full list in Supplementary Data 6). All expressed genes were used as background. b Network of target genes associated with the GO term “SMAD complex assembly” (large nodes) and their first interactors (small nodes). c GO terms related to “muscle” and “mesenchyme” that were enriched among the target genes of the PAH-specific GRN. d Network of target genes associated with the GO terms “Smooth muscle differentiation” and/or “Smooth muscle contraction” (large nodes) and their first interactors (small nodes). Color code as in b. e Network of target genes associated with the GO terms “Regulation of epithelial to mesenchymal transition” (large nodes) and their first interactors (small nodes). Color code of the nodes as in b.

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