Fig. 5: Adipocyte-specific ASK1 overexpression decreases adipose tissue browning.
From: ASK1 inhibits browning of white adipose tissue in obesity
a Protein levels of ASK1 in lysate of isolated adipocytes harvested from CAG-ASK1F/F and CAG-ASK1+adipo mice (n = 2 mice per group). b mRNA expression of respective genes in inguinal adipose tissue of cold-exposed CAG-ASK1F/F (n = 5) and CAG-ASK1+adipo (n = 6) mice. #p = 0.094, *p = 0.042, *p = 0.017. c, d Representative western blot and quantification of UCP1 protein levels in inguinal adipose tissue harvested from cold-exposed CAG-ASK1F/F (n = 7) and CAG-ASK1+adipo (n = 8) mice. *p = 0.037. Values are expressed as mean ± SEM. Statistical tests used: two-sided t-tests for (b) (Ucp1 and Pgc1α), d two-sided Mann–Whitney for (b) (Cidea). Source data are provided as a Source Data file.
