Fig. 3: Cfz treatment leads to prominent intron retention. | Nature Communications

Fig. 3: Cfz treatment leads to prominent intron retention.

From: Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma

Fig. 3

a Cartoon description of alternative splicing event (ASE) types and description of ΔPSI. b Histograms of ΔPSI for JuncBASE identified ASEs in MM.1S treated with 18 nM Cfz stratified according to type of splicing event (IR = yellow, alt. exon cassette = teal, alt. exon donor (5’ splice site) = pink, alt. exon acceptor (3’ splice site) = blue, alt. first exon = green, alt. last exon = purple). Bin = 2, red line indicates ΔPSI = 0. c Histograms of ΔPSI for all IR events (top panel) and Alt. exon donor events (bottom panel) in AMO-1 treated with 15 nM Cfz. d Histograms of ΔPSI for all IR events (top panel) and Alt. cassette events (bottom panel) in MM.1S treated with 10 μM melphalan. e Top ranked GO enrichment terms for genes with significant (p < 0.05) ASEs for MM.1S cells treated with 18 nM Cfz (left panel) or with 10 μM melphalan (right panel).

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