Fig. 6: Abnormal synaptic function in male MG4E mice.
From: Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
a mEPSCs recorded in mPFC layer 5 neurons of male control and MG4E mice at 6–7 weeks of age. n = 20 cells from five control mice and 33 cells from 8 MG4E mice. Two-sided t-test for frequency and amplitude: **p = 0.0022; n.s. not significant. Two-sided Kolmogorov–Smirnov test for cumulative probability of mEPSC amplitude: ***p < 0.001. Scale bars, 50 pA (vertical) and 0.5 s (horizontal). b mIPSCs recorded in mPFC layer 5 neurons of male control and MG4E mice at 6–7 weeks of age. n = 17 cells from 4 control mice and 25 cells from 6 MG4E mice. Two-sided t-test for frequency (p = 0.6053) and amplitude (p = 0.1097): n.s. not significant. Two-sided Kolmogorov–Smirnov test for cumulative probability of mIPSC amplitude: ***p < 0.001. Scale bars, 25 pA (vertical) and 0.5 s (horizontal). c Relative changes in mEPSC (n = 33 cells) and mIPSC (n = 25 cells) total charge transfer in MG4E mice, normalized to control mice. p = 0.0453 by two-sided Kolmogorov–Smirnov test. All data are shown as mean ± s.e.m. Source data are provided as a Source Data file.
