Fig. 5: Structure analysis of Sox2-HMG/nucleic acid-binding modes. | Nature Communications

Fig. 5: Structure analysis of Sox2-HMG/nucleic acid-binding modes.

From: The Sox2 transcription factor binds RNA

Fig. 5

a 1H–15N HSQC NMR spectrum of Sox2-HMG (black) overlaid with the spectrum of the Sox2-HMG/DNA complex (red). The DNA sequence used in this experiment was derived from the FGF4 enhancer, corresponding to the sequence shown in Supplementary Table 1. b 1H–15N HSQC NMR spectrum of Sox2-HMG (black) overlaid with the spectrum of the Sox2-HMG/RNA complex (blue). The RNA sequence used in this experiment was the hairpin Loop B/Bulge(0 + 1) (Fig. 3c).

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