Fig. 2: Portal-capsid interactions in the symmetry-mismatched vertex.
From: Structural morphing in a symmetry-mismatched viral vertex
a Arrangement of the portal and capsid subunits in the in situ structure. The gp20 subunits and gp23* subunits are colored and labeled as in Fig. 1a (S and D gp23* subunits in magenta and cyan, respectively, and alternative gp20 subunits in blue and orange). For clarity, only the N-terminal 70 residues, loop Asp209-Lys227, and hairpin Arg185-Glu204 of each gp20 subunit that make contacts with the capsid are shown and one of the subunits is enlarged. The two potential methionine-metal clusters are indicated by red arrows. b Schematic diagram showing the symmetry mismatch between the portal assembly and the capsid. c, d Charge interactions between the portal and its surrounding gp23* capsomers showing a morphing relationship between p, p + 5, and p + 7 portal subunits to compensate for the symmetry mismatch.
