Table 1 Comparison of synthetic and native DNA-based data storage platforms.

From: DNA punch cards for storing data on native DNA sequences via enzymatic nicking

DNA-based storage method

Writing latency

Reading latency

Enables computation?

Bit-wise random access

Maximum achievable physical density

Information density

(Optimal)coding loss10

Synthesis-based

Sequential de novo synthesis/ hours

NGS/hours

×

×

200 Ebytes/g9

<2 bits/bp (to account for coding loss, usually ~1.5 bits/bp)

21%10,11

This work

Parallel nicking/<40 min

NGS followed by reference alignment/ hours

✔□

✔□

4 Ebytes/g

0.036 bits/bp

0%

  1. Native DNA-based platforms outperform synthetic DNA-based approaches in all performance categories, except for storage density.
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