Fig. 1: The effect of partial peripheral tissue IR disruption on body composition and energy expenditure in adult mice fed a high-fat diet. | Nature Communications

Fig. 1: The effect of partial peripheral tissue IR disruption on body composition and energy expenditure in adult mice fed a high-fat diet.

From: Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Fig. 1: The effect of partial peripheral tissue IR disruption on body composition and energy expenditure in adult mice fed a high-fat diet.The alternative text for this image may have been generated using AI.

Ten days following tamoxifen (TX) treatment, male mice were fed a high-fat diet (HFD) and liver insulin receptor (IR) β expression a, body mass b, body composition c, d, food intake e, energy expenditure (EE) f, respiratory exchange ratio (RER) g and activity levels h were determined, as well as plasma leptin i. Results are shown as means ± SE, with n’s represented as individual data point’s in figures. For body weight n = 13 for WT and 17 for PerIRKO+/−. Significance was determined using two-tailed student’s t test. *p < 0.05, ***p < 0.001 vs WT. Gastroc: gastrocnemius muscle, TA: tibialis anterior muscle, Sub: subcutaneous, visceral fat is the epididymal fat pad.

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