Fig. 3: Partial peripheral tissue IR disruption induces an energy defect in the liver of adult mice fed a high-fat diet. | Nature Communications

Fig. 3: Partial peripheral tissue IR disruption induces an energy defect in the liver of adult mice fed a high-fat diet.

From: Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Fig. 3: Partial peripheral tissue IR disruption induces an energy defect in the liver of adult mice fed a high-fat diet.The alternative text for this image may have been generated using AI.

Ten weeks following high-fat diet (HFD) feeding the livers of male WT and PerIRKO+/− were collected and AMPK activation (phosphorylation), PGC1α expression a, ATP, ADP, AMP levels b, expression of glucose metabolism genes c, and glycogen content d was determined. Results are shown as means ± SE, with n’s represented as individual data point’s in figures. Significance was determined using two-tailed student’s t test; *p < 0.05, **p < 0.01, ***p < 0.001 vs WT.

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