Fig. 5: scRNA-seq identifies CTHRC1+ pathologic fibroblasts in human fibrotic lungs. | Nature Communications

Fig. 5: scRNA-seq identifies CTHRC1+ pathologic fibroblasts in human fibrotic lungs.

From: Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

Fig. 5: scRNA-seq identifies CTHRC1+ pathologic fibroblasts in human fibrotic lungs.The alternative text for this image may have been generated using AI.

a UMAP plot of all cells acquired by scRNA-seq of human samples. Cells were obtained from three normal lungs (green), three IPF lungs (red), and two scleroderma lungs (blue). b COL1A1 expression on UMAP plot. See Supplementary Fig. 5a for lineage identification. DC, dendritic cells; Mac, macrophage. c UMAP plot of COL1A1+ cells. d Unsupervised clustering identified 7 clusters. e Expression levels of representative genes are shown on UMAP plots. f Expression of COL1A1, CTHRC1, and ACTA2 are shown on UMAP plots. Cells from normal, IPF, and scleroderma lungs are shown separately in each column. g Expression levels of selected ECM genes on UMAP plots.

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