Fig. 2: GWAS meta-analysis results for asthma. | Nature Communications

Fig. 2: GWAS meta-analysis results for asthma.

From: Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Fig. 2

Of the 66 previously unknown loci, 58 were significantly associated with asthma in the meta-analysis with the UK Biobank and TAGC (red dots). Eight loci were associated with asthma in the GWAS analysis with the UK Biobank alone but fell slightly below the genome-wide significance threshold in the meta-analysis with the TAGC (light blue dots). The Z-score meta-analysis included a total of 88,486 cases and 447,859 controls from the UK Biobank (64,538 asthma cases and 329,321 controls) and TAGC (23,948 asthma cases and 118,538 controls) and 8,365,359 SNPs common to both datasets. Genome-wide thresholds for significant (P = 5.0 × 10−8) and suggestive (P = 5.0 × 10−6) association are indicated by the horizontal red and dark blue lines, respectively. P-values are truncated at −log10(P) = 30.

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