Fig. 3: Cumulative genetic burden and risk of asthma in the UK Biobank. | Nature Communications

Fig. 3: Cumulative genetic burden and risk of asthma in the UK Biobank.

From: Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Fig. 3

a Individuals in the highest decile for three weighted genetic risk scores (GRS) based on the known or previously unreported susceptibility loci have significantly elevated risk for asthma compared to the lowest decile. b–d Compared to females, cumulative genetic risk for asthma was more significantly pronounced in males across the entire spectrum of sex-specific weighted GRS constructed from all 212 (P-int = 6.1 × 10−18), 146 known (P-int = 3.0 × 10−18), and 66 previously unknown (P-int = 0.01) loci. Interactions with sex were also significant when comparing the highest versus lowest decile for the GRS constructed from all 212 (P-int = 7.3 × 10−10), 146 known (P-int = 1.9 × 10−10), and 66 previously unknown (P-int = 0.03) loci. Each decile in the GRS analyses included 39,386 subjects when both sexes were combined (a) or 18,318 males and 21,068 females when stratified by sex (b–d). Data are shown as ORs with 95% CIs, as calculated by logistic regression.

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