Fig. 1: Reduction in β2-adrenergic signaling enhances the abscopal effect in a CT26 colon carcinoma model. | Nature Communications

Fig. 1: Reduction in β2-adrenergic signaling enhances the abscopal effect in a CT26 colon carcinoma model.

From: Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation

Fig. 1: Reduction in β2-adrenergic signaling enhances the abscopal effect in a CT26 colon carcinoma model.The alternative text for this image may have been generated using AI.

BALB/c mice were implanted with CT26 tumors bilaterally; one tumor was irradiated. Tumor growth is shown for irradiated tumors (left) and non-irradiated tumors (right). a In mice housed at 22 °C (ST) or 30 °C (TT); b and c Comparison of tumor growth in BALB/c b or SCID mice c, which received no treatment, propranolol alone, radiation alone, or the combination; d Comparison of tumor growth in WT or β2-AR KO mice which received no treatment, propranolol alone, radiation alone, or the combination. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01; ****P < 0.0001 (two-way ANOVA analysis). For a, n = 9 biologically independent mice in 22 °C, 30 °C and Rad + 30 °C groups, n = 7 biologically independent mice in Rad + 22 °C group; for b, n = 6 biologically independent mice in PBS, Prop, and PBS + Rad groups, n = 5 biologically independent mice in Prop + Rad group; for c, n = 10 biologically independent mice in all groups; for d, n = 6 biologically independent mice in WT PBS + Rad and KO PBS + Rad groups, n = 7 biologically independent mice in WT Prop + Rad group, n = 8 biologically independent mice in KO Prop + Rad group.

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