Fig. 7: The relationship between liver fat composition and hepatic insulin sensitivity. | Nature Communications

Fig. 7: The relationship between liver fat composition and hepatic insulin sensitivity.

From: Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Fig. 7

The relationship between hepatic IS (EGP suppression) and a total liver fat content, b SFA fraction, c MUFA fraction, d PUFA fraction, and e MUFA/SFA ratio in overweight and obese individuals (healthy with and without NAFL in black and patients with T2D in red, n = 30 for total liver fat content and n = 29 for the fatty acid fractions and MUFA/SFA ratio). The correlation coefficient is shown in the respective plots (Two-sided Spearman correlation). f EGP suppression in healthy overweight/obese without NAFL (controls, n = 7), overweight/obese with NAFL (n = 14), and patients with T2D (n = 9). EGP suppression in patients with T2D was significantly lower compared to controls (p = 0.002). Data are presented as mean with error bars showing the SEM. Different letters indicate significant differences between groups (one-way ANOVA, p < 0.05). Bonferroni correction was used for post-hoc analyses.

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