Fig. 2: Burden of coding ultra-rare SNVs and indels.

X-axis: annotation class. Y-axis: odds ratio. Legend: exomes: coding variants in all genes; LOFtol: in genes tolerant to loss-of-function variation; LOFintol: in genes intolerant to loss-of-function variation. For each specific burden test, we used a vertical line to indicate the 95% confidence interval of odds ratio and a dot at the center of the vertical line to indicate the point estimate of odds ratio.