Fig. 6: Super-resolution imaging of disrupted heterochromatin structure in human neoplasia.
a–c Representative histology and corresponding super-resolution images of heterochromatin structure for colorectal neoplastic lesions together with their paired normal tissue located at more than 10 cm away from the tumor. Scale bars: 2 µm. d The radial distribution functions (RDF) for characterization of H3K9me3-dependent heterochromatin structure for the normal-tumor pairs. All P values between two groups are P < 10−20. e The average H3K9me3 cluster size for a total of 19 patient samples (patient information shown in Supplementary Table 1) including five normal tissue from non-neoplastic patients, five adenoma or low-grade dysplasia (LGD), four high-grade dysplasia and five invasive colorectal cancer. Each point is the average of over 100 cell nuclei for each patient. All P values were determined using Mann−Whitney test.
