Fig. 6: Comparing spike imaging and ictal imaging results.

a Localization error for spike and ictal imaging results are presented. Each gray circle corresponds to individual patient’s data. The red bar indicates the mean, the color bars indicate the 95% confidence interval for the mean and the dark bars indicate the standard deviation. The localization error in all patients (n = 16) showed a significant difference (*p < 0.05) between the ictal and interictal imaging results (one-sided permutation test, p = 0.0015). Same results were observed for non-seizure-free patients (n = 7, one-sided permutation test, p = 0.004), while seizure-free patients did not show such a strong trend (n = 9, one-sided permutation test, p = 0.0476). b Geometric mean for spike and ictal imaging results; organization is same as in a. The geometric mean in all patients (n = 29 for spike analysis and n = 28 for ictal analysis) showed a significant difference (*p < 0.05) between the ictal and interictal imaging results (one-sided permutation test, p = 0.0195). Same results were observed for non-seizure-free patients (n = 9, one-sided permutation test, p = 0.0236), while seizure-free patients did not show such a trend (n = 20 for spike analysis and n = 19 for ictal analysis, one-sided permutation test, p = 0.14). c Spike and ictal imaging results in one patient along the clinical findings in this patient. This particular patient had two major spike types and belonged to the non-seizure-free group. d Spike and ictal imaging results in one patient along the clinical findings in this patient. This particular patient had one major spike type and belonged to the seizure-free group. Source data are provided as a Source Data file. Color scales and definitions for c, d are the same as Fig. 5.