Fig. 5: Mis-expression of SRGs in PCa. | Nature Communications

Fig. 5: Mis-expression of SRGs in PCa.

From: Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

Fig. 5

Integrated heatmap of differentially expressed SRGs identified in Oncomine (p < 0.05) and RNA-seq (fold change (FC) ≥ 1.5 and FDR < 0.1 calculated by DESeq2 v.1.18.1). In Oncomine (O), the medium-rank of <2500, <4000, and >4000 for a gene denotes high, moderate, and low levels of expression, respectively. The rank for a gene is the median rank for that gene across each of the analyses. The p-value for a gene is its p-value for the median-ranked analysis. For visualization, DEGs revealed by RNA-seq (R) data are categorized into three groups according to FC differences (FC ≥ 3, ≥2, and ≥1.5). Based on pairwise comparisons, the stages of PCa are defined as tumor development (pri-PCa vs. normal tissues), ADT treatment response (ADT-after vs. -before), CRPC progression (CRPC-Ad vs. pri-PCa), and plasticity (CRPC-NE vs. CRPC-Ad). Also see Supplementary Fig. 11 and 12, and Supplementary Data 4.

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