Fig. 5: Myeloperoxidase function is important during swarming control of C. albicans germination and growth.
From: Neutrophil swarming delays the growth of clusters of pathogenic fungi
C. albicans germinates faster in swarms treated with ABAH. N = 40 swarms across 3 donors (a). Fungal hyphae escape faster in swarms during MPO inhibition. N = 40 swarms across 3 donors (b). MPO inhibition results in more fungal growth at 16 hours. Results are normalized to the growth of the C. albicans alone control. N = 240 swarms over 3 donors (c). The MFI of C. albicans was quantified over 12 hours with and without MPO inhibition. N = 16 swarms from a representative donor (d). MPO inhibition does not impact NET release during swarming. The MFI of Sytox Green was quantified over 12 hours. N = 16 swarms from a representative donor (e). ****p <0.0001 Students T-test for a–b, two-tailed Mann-Whitney test for c (unpaired, two-tailed). Error bars represent mean +/− standard deviation for (a–c) and mean +/− standard error for (d–e).
