Fig. 4: Outcomes at 12-month follow-up according to baseline VMB composition at baseline. | Nature Communications

Fig. 4: Outcomes at 12-month follow-up according to baseline VMB composition at baseline.

From: The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions

Fig. 4

A Lactobacillus spp.-depleted VMB (a) and CST IV (b) were associated with significantly lower rates of regression compared to non-regression at 12 months. Significantly higher species richness (species observed) was seen in women who had not regressed at 12 months follow-up (p = 0.0091), with diversity (Inverse Simpson index) also increased but this was not significant (c). The baseline vaginal microbiota of women who did not regress at 12 months was characterised by an increased abundance of Megasphaera (unclassified) (p = 0.0038, q = 0.081), Prevotella timonensis (p = 0.015, q = 0.153), Gardnerella vaginalis (p = 0.036, q = 0.252) and BVAB1 (p = 0.043, q = 0.228) (d). Data are represented as percentages in a, b and c as mean ± standard error of mean in d. The p-values by two-tailed unpaired t-test in c, and by Welch’s t-test in d. Dots in c and d depict individual patients. (n = 87, ***p < 0.001; **p < 0.01; *p < 0.05). Source data are supplied as a Source Data File. CST I Lactobacillus crispatus-dominant, CST III Lactobacillus iners-dominant, CST IV Lactobacillus spp.-depleted, high diversity.

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