Fig. 1: OMP and cAMP docking simulation. | Nature Communications

Fig. 1: OMP and cAMP docking simulation.

From: Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Fig. 1: OMP and cAMP docking simulation.The alternative text for this image may have been generated using AI.

a Primary structure of M. musculus OMP. b, c Docking results of OMP (ribbons) and two cAMP molecules (balls). d The calculated surface electron clouds of OMP are shown in white with two cAMP molecules docked. e–h cAMP and the surrounding residues at sites A and B viewed from the top (e, g) and laterally (f, h). The residues shown in yellow were mutated in the following experiments. i Comparison of OMP primary structures among different vertebrate species. The highly conserved residues are indicated with coloured letters. Residues comprising sites A and B are highlighted in red and blue, respectively. The classical consensus sequence of CNBD is highlighted by a purple box. j Evolutionary relationships of OMP. k, l The conserved residues on the surface of the OMP space-filled structure on the face (k) and back (l) are coloured pink.

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