Fig. 3: Pregnant women with NAFLD and ICP had increased risk for PTB with elevated sTBAs.
From: Dysregulation of bile acids increases the risk for preterm birth in pregnant women
a The PTB rates, sTBA levels, and their correlations in all subjects (n = 36,755) and the subjects with NAFLD (n = 1554) or ICP (n = 505). The box and whisker plots of the middle panel show the maximum, minimum data points, median value, and 75th and 25th quartile. Data points for serum TBA are presented as mean ± SD in the right panel. b The sTBA levels in the subjects with FTB (n = 1337 for NAFLD, n = 388 for ICP) and PTB (n = 217 for NAFLD, n = 117 for ICP) among the pregnant women with NAFLD or ICP. The box and whisker plots show the maximum, minimum data points, median value, and 75th and 25th quartile. c Serum AST levels in all subjects (n = 36,755) and subjects with NAFLD (n = 1554) or ICP (n = 505). The AST levels correlated with the rates of PTB. The box and whisker plots in the left panel show the maximum, minimum data points, median value, and 75th and 25th quartile. The data points for AST levels are presented as mean ± SD in the right panel. d The AST levels in subjects with FTB (n = 1337 for NAFLD and n = 388 for ICP) and PTB (n = 217 for NAFLD and n = 117 for ICP) among the pregnant women with NAFLD or ICP. The box and whisker plots show the maximum, minimum data points, median value, and 75th and 25th quartile. Student’s t test for pairwise comparison or one-way ANOVA, followed by Tukey post hoc test for multiple group comparison were applied for statistical analysis. Source data are provided as a Source Data file.
