Fig. 8: Prevention of PTB by restoring bile acid homeostasis through FXR activation in pregnant mice.
From: Dysregulation of bile acids increases the risk for preterm birth in pregnant women
a The gestation days, PTB rates, and the rates of live birth in mice treated with CCl4 alone (1.5 ml kg−1) (n = 9) or a combination of CCl4 (1.5 ml kg−1) and FXR agonist GW4064 (50 mg kg−1) (n = 13). b The sTBA and AST levels in mice treated with CCl4 alone (n = 9) or a combination of CCl4 and GW4064 (n = 11) and a positive correlation between sTBA and AST levels. c The relative expression levels of mRNAs for Bsep, Cyp7a1, Shp, and Fxr in mice treated with CCl4 (n = 9) or a combination of CCl4 and GW4064 (n = 11). The means and standard errors of the group values were indicated by the long and short lines, respectively. Student’s t test for pairwise comparisons (two-sided) and Chi-squared test for proportion comparisons were applied for statistical analysis. Pearson correlation analysis was applied to determine the correlation coefficient and associated p values. Source data are provided as a Source Data file.
