Fig. 2: Prefrontal-limbic circuit TSPO availability was lower in the PTSD vs. control group. | Nature Communications

Fig. 2: Prefrontal-limbic circuit TSPO availability was lower in the PTSD vs. control group.

From: PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

Fig. 2

[11C]PBR28 VT in the prefrontal-limbic circuit composed of amygdala, anterior cingulate cortex, hippocampus, insula, and vmPFC, was lower (F5,41 = 2.46, p = 0.049) in the PTSD (pink triangles, n = 23) compared to control (green circles, n = 26) group. A 14% difference in [11C]PBR28 VT between groups was observed in insula (p = 0.036) and vmPFC (p = 0.023). Group differences were assessed using MANOVA and within-ROI comparisons assessed using ANOVA. Displayed [11C]PBR28 VT values are adjusted for genotype and sex, with group-wise mean indicated by black point. AMYG: amygdala, ACC: anterior cingulate cortex, HIPP: hippocampus, INS: insula, VMPFC: ventromedial prefrontal cortex. *p < 0.05, not corrected for multiple comparisons.

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